An individual with Type 2 diabetes displays sustained hyperglycemia despite increased insulin levels. Which signaling defect most likely explains this phenomenon?

💡 Explanation

Insulin resistance decreases GLUT4 translocation, impairing glucose uptake by cells, because cells fail to respond adequately to insulin signals. Therefore, hyperglycemia persists despite high insulin, rather than increased receptor internalization, beta-cell production, or increased glycogen synthesis.

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