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← Human Body & HealthDuring in-vitro fertilization (IVF), a drug inhibits granulosa cell aromatase activity within ovarian follicles. Which outcome is most likely?
A)Elevated circulating inhibin B levels
B)Increased progesterone receptor expression
C)Stimulation of LH surge prematurely
D)Decreased intrafollicular estradiol production✓
💡 Explanation
Aromatase converts androgens to estrogens within ovarian follicles. Inhibiting aromatase reduces estradiol synthesis because the aromatization mechanism is blocked, therefore intrafollicular estradiol decreases, rather than other hormonal changes that would normally result from estradiol stimulation.
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