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Human Body & Health

Following blunt trauma to the spleen, what causes disseminated intravascular coagulation (DIC) due to widespread platelet aggregation?

A)Increased antithrombin III production
B)Inhibition of plasminogen activators
C)Release of tissue factor into circulation
D)Elevated levels of protein C activation

💡 Explanation

DIC following splenic trauma arises because the damaged spleen releases tissue factor into the circulation, which initiates the coagulation cascade, leading to excessive platelet aggregation and fibrin formation. Therefore, option C is correct; rather than antithrombin III increase which inhibits coagulation.

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