If a drug is administered intravenously to a patient and exhibits a larger volume of distribution than expected based on body weight alone, which consequence follows?

💡 Explanation

A larger volume of distribution indicates the drug is accumulating in tissues outside the plasma; because the drug leaves the central compartment, its elimination from the plasma slows, leading to a prolonged half-life. Therefore, half-life increases, rather than rapid clearance or altered metabolism, which are independent processes.

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