Why does chronic inflammation in rheumatoid arthritis promote angiogenesis within the synovial fluid?

💡 Explanation

In rheumatoid arthritis, chronic inflammation increases vascular endothelial growth factor (VEGF). This, via the VEGF pathway, promotes angiogenesis by overwhelming natural inhibitors, leading to new blood vessel formation within the synovium. Therefore, elevated VEGF causes angiogenesis, rather than its suppression or a reduction in TNF-alpha or enhanced TGF-beta.

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