Why does targeted growth factor receptor therapy sometimes fail to induce apoptosis in cancer cells despite initial success?

A)Increased MHC-I antigen presentation overwhelms killing

B)Drug efflux pump expression increases quickly

C)Checkpoint adaptation bypasses growth inhibition signal✓

D)Telomere shortening induces premature senescence

💡 Explanation

Cancer cells can develop resistance through checkpoint adaptation, bypassing the growth inhibition signal from targeted therapy. This occurs because alternative signaling pathways are activated, allowing cell cycle progression despite receptor blockade; therefore, apoptosis is not induced, rather than cell death resulting directly from drug efflux.

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Why does targeted growth factor receptor therapy sometimes fail to induce apoptosis in cancer cells despite initial success?

💡 Explanation

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