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Human Body & Health

Why does excessive omega-6 fatty acid intake increase the risk of chronic inflammatory diseases, impairing inflammation resolution?

A)Stimulates PPAR-gamma receptor activity
B)Enhances IL-10 cytokine production
C)Favors pro-inflammatory eicosanoid production
D)Increases specialized pro-resolving mediators (SPMs)

💡 Explanation

Excessive omega-6 intake favors the production of pro-inflammatory eicosanoids (prostaglandins, leukotrienes) via the COX pathway, which sustains inflammation because these mediators actively promote inflammatory signaling, rather than facilitating resolution. Therefore, the answer is C, rather than B, D, or A, which all would promote inflammation resolution under normal conditions.

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