If a genetically modified T-cell with a chimeric antigen receptor (CAR) encounters its target cancer cell, which consequence follows regarding local inflammation?

💡 Explanation

A CAR T-cell encountering its target causes massive T-cell activation and cytokine release, thus a cytokine storm becomes a major risk. This is because CARs bypass normal T-cell activation controls; therefore, the acute inflammation risk increases rather than decreases for the other cellular elements.

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