If a patient undergoing a kidney transplant develops immediate hypersensitivity to a previously tolerated immunosuppressant drug (e.g., after prior sensitization), which consequence is most likely?

💡 Explanation

Immediate hypersensitivity, like a drug allergy, involves sensitization leading to IgE production. Upon subsequent exposure, the drug crosslinks IgE on mast cells, triggering degranulation and histamine release, because histamine mediates allergic symptoms. Therefore, mast cell degranulation is the correct outcome, rather than metabolic changes or immune complex formation.

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