If a patient consistently maintains high urine pH while taking calcium supplements, which consequence affecting kidney stone formation is most likely?

💡 Explanation

High urine pH reduces the solubility of calcium oxalate because it promotes calcium phosphate formation, drawing calcium away from oxalate. While elevated urine pH can increase the risk of phosphate stones, in the presence of calcium supplements, the net effect is increased calcium oxalate supersaturation. Therefore, oxalate concentrations rise, rather than decrease, and calcium oxalate stones become more likely.

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