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Human Body & Health

In a patient with diabetes insipidus lacking ADH, which consequence follows regarding the kidney's countercurrent multiplier system?

A)Urine osmolarity will sharply increase
B)Sodium reabsorption will significantly increase
C)Medullary osmotic gradient weakens severely
D)Potassium secretion is greatly enhanced

💡 Explanation

Without ADH, the collecting duct's permeability to water decreases, impairing water reabsorption driven by the osmotic gradient. The countercurrent multiplier establishes this medullary gradient; therefore, the impaired water reabsorption weakens the gradient rather than increasing sodium reabsorption or urine osmolarity.

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