If a patient exhibits persistent cognitive deficits post-concussion, even after initial symptoms subside, which mechanism explains the ongoing dysfunction at the neuronal level?

💡 Explanation

Persistent cognitive deficits often arise from diffuse axonal injury. Because the concussion generates shear strain, it stretches and damages axons throughout the brain, disrupting neural network integrity and function. Therefore, widespread axonal damage is the primary driver of lasting dysfunction, rather than localized contusions or altered CSF dynamics.

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