If a patient exhibits severe muscle weakness and neurological dysfunction despite adequate protein intake, which cofactor-related deficiency is the MOST likely underlying cause?

💡 Explanation

Thiamine, or Vitamin B1, is essential as a cofactor for enzymes like pyruvate dehydrogenase in carbohydrate metabolism; because a deficiency impairs ATP production, neural and muscular tissues suffer, therefore neurological and muscular dysfunction occurs rather than issues directly involving other vitamins or minerals.

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