If a patient has a mutation causing a non-functional thiamine pyrophosphate (TPP)-dependent enzyme in the pentose phosphate pathway, which consequence becomes most likely?

💡 Explanation

Because the pentose phosphate pathway relies on TPP for key enzymatic reactions, a non-functional enzyme means NADPH production decreases. Therefore, cells have less capacity to deal with oxidative stress, rather than elevated serotonin, or increased oxygen binding which are unrelated.

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