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Human Body & Health

If a patient reports chronic pain following a nerve injury where A-beta fibers now activate pain pathways in the spinal cord, which consequence follows?

A)Increased endorphin receptor sensitivity
B)Allodynia via central sensitization
C)Reduced substance P neurotransmission
D)Elevated descending inhibitory signaling

💡 Explanation

Allodynia, pain from non-painful stimuli, can result from central sensitization because nerve damage can cause A-beta fibers to trigger nociceptor pathways. This altered transmission leads to pain perception, therefore the correct answer is allodynia rather than endorphin release, substance P reduction, or increased inhibition which would reduce pain.

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