If a patient's dehydration increases plasma osmolality, and ADH secretion is suppressed due to a rare collecting duct aquaporin-2 mutation, which consequence follows?

💡 Explanation

The collecting duct's aquaporin-2 channels mediate water reabsorption driven by ADH. Because the mutation impairs this mechanism despite increased plasma osmolality, water reabsorption fails, leading to excessive diuresis, therefore resulting in dilute urine, rather than concentrated urine due to normal ADH function.

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