If a patient undergoes gastric bypass surgery, what hormonal change is most likely to promote long-term weight loss?

💡 Explanation

Gastric bypass enhances GLP-1 secretion, promoting satiety and decreasing appetite because the rapid delivery of nutrients to the distal small intestine stimulates L-cells. Therefore, enhanced GLP-1 signaling helps maintain weight loss rather than reducing leptin sensitivity or increasing ghrelin.

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