If a patient with a non-functional filaggrin gene (involved in keratinocyte aggregation) sustains a deep dermal abrasion, which consequence regarding healing is most likely?

💡 Explanation

Filaggrin is crucial for keratinocyte aggregation and proper epidermal barrier formation. Without functional filaggrin, the epidermal barrier's ability to restore itself after abrasion is impaired because the cornification process is disrupted, therefore impeding wound closure, rather than accelerating collagen remodeling or other inflammatory responses.

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