If a patient with Ehlers-Danlos syndrome (weakened collagen) sustains a deep dermal wound, which consequence involving matrix metalloproteinases (MMPs) is most likely to occur during the healing process?

💡 Explanation

Ehlers-Danlos syndrome results in structurally weak collagen. MMPs, responsible for collagen remodeling during wound healing, will excessively degrade the already compromised collagen because of its reduced stability. Therefore, increased degradation occurs, rather than accelerated differentiation, reduced angiogenesis, or diminished keratinocyte migration which are less directly impacted by the initial collagen weakness.

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