If a patient with iodine deficiency develops a goiter and receives excessive supplemental iodine, what homeostatic disturbance is most likely to occur initially?

💡 Explanation

Excess iodine can trigger the Wolff-Chaikoff effect, wherein high intracellular iodide levels acutely inhibit thyroid peroxidase (TPO), reducing thyroid hormone synthesis. Because of this autoregulatory mechanism, thyroid hormone synthesis is transiently suppressed, therefore D is correct, rather than options that involve sustained hyperthyroidism.

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