If a patient with rheumatoid arthritis has increased levels of TNF-alpha, which consequence follows regarding inflammation?

💡 Explanation

Increased TNF-alpha in rheumatoid arthritis leads to greater NF-kB activation because TNF-alpha activates its receptor, triggering a signaling cascade that results in NF-kB translocation to the nucleus and subsequent expression of pro-inflammatory genes; therefore, increased NF-kB activity results, rather than decreased activity or direct effects on vascular permeability or prostaglandin synthesis.

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