If a patient with type 2 diabetes displays persistent hyperglycemia despite insulin injections and normal insulin receptor binding, which consequence affecting GLUT4 translocation is most likely?

💡 Explanation

In insulin resistance, the downstream signaling cascade after insulin receptor binding is impaired, often affecting the ability of GLUT4-containing vesicles to fuse with the plasma membrane. Therefore, impaired vesicle fusion reduces GLUT4 insertion, rather than receptor internalization, altered glycogen synthase, or glucagon receptor expression, because these are separate mechanisms.

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