Why does histamine release in localized inflammation increase capillary permeability rather than decrease it, given the immune system's goal of containing infection?

💡 Explanation

Histamine increases capillary permeability to allow immune cells and complement proteins to exit the bloodstream and reach the site of infection; because increased permeability allows these factors to reach the tissues, therefore extravasation is facilitated, rather than limiting access to the site via constriction.

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