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Human Body & Health

If a pharmaceutical company aims to reduce inflammation by targeting the NF-κB signaling pathway, which consequence involving cytokine production is most likely?

A)Increased prostaglandin E2 production
B)Decreased transcription of pro-inflammatory cytokines
C)Enhanced COX-2 enzyme activity systemically
D)Upregulation of TNF-α receptor expression

💡 Explanation

Inhibiting the NF-κB pathway reduces the expression of genes encoding pro-inflammatory cytokines like TNF-α and IL-6, because NF-κB is a key transcription factor for these cytokines. Therefore, the transcription of pro-inflammatory cytokines will decrease, rather than increase other inflammatory mediators like prostaglandins.

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