If a pharmaceutical company develops a highly selective antagonist for the neurokinin-1 (NK1) receptor in the dorsal horn, which consequence follows regarding pain perception?

💡 Explanation

Blocking the NK1 receptor prevents substance P from binding, which reduces the transmission of pain signals in the spinal cord because substance P is a key neurotransmitter in nociceptive pathways. Therefore, pain perception is diminished, rather than enhanced peripheral sensitization or increased inflammation.

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