If a researcher selectively deactivated filaggrin production in human epidermal cells cultured in vitro, which consequence is most likely?

💡 Explanation

Filaggrin is crucial for aggregating keratin filaments within epidermal cells and forming the skin barrier. Deactivating filaggrin impairs the proper assembly of this barrier because the structural integrity of the stratum corneum diminishes; therefore, barrier function declines, rather than triggering melanin synthesis or impacting collagen/sebum production directly.

• If the vagus nerve signaling to the stomach is chronically reduced, which consequence follows regarding gastric emptying and nutrient absorption?
• Why does increased mechanical loading from high-impact exercise initially weaken bone before strengthening via remodeling?
• If the aorta's elastic fibers degrade, increasing arterial stiffness in a patient with hypertension, which consequence follows related to baroreceptor feedback?
• If a drug inhibits pancreatic beta cell glucokinase in a patient with Type 2 diabetes already exhibiting insulin resistance, which consequence follows?
• If a retinal detachment separates photoreceptors from the retinal pigment epithelium (RPE), which consequence follows, hindering vision?
• A patient with liver cirrhosis experiences prolonged bleeding after a minor injury. Which mechanism explains why reduced fibrin crosslinking leads to this bleeding tendency?