If a viral infection triggers excessive production of IL-1β cytokine in lung tissue, which consequence follows regarding inflammation resolution?

💡 Explanation

Elevated IL-1β stimulates COX-2 and prostaglandin E2 (PGE2) production, sustaining inflammation, because PGE2 promotes vasodilation and immune cell recruitment. Therefore, inflammation is prolonged, rather than being resolved by neutrophil apoptosis or lipoxins, which have anti-inflammatory effects.

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