If an influenza vaccine induces a weak initial antibody response, which process must improve to enhance long-term immunity following a booster?

💡 Explanation

For a weak initial response, long-term immunity depends on B cell affinity maturation because it refines antibody binding to the influenza virus, generating higher-affinity antibodies and memory B cells. Therefore, affinity maturation is crucial, rather than increased MHC presentation or complement activation, which impact initial immune activation.

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