If an oral drug formulation exhibits high lipophilicity, and the patient has compromised liver function, which consequence follows regarding the drug's systemic availability?

💡 Explanation

High lipophilicity generally promotes absorption, but compromised liver function impairs the first-pass metabolism. Because the liver cannot effectively process the drug, more of it avoids systemic circulation, therefore the bioavailability drastically reduces, rather than other effects such as altered absorption or excretion.

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