If epidermal keratinocytes chronically overproduce keratin intermediate filaments but show reduced cornification enzyme activity, which consequence follows?

💡 Explanation

Impaired skin barrier formation occurs because keratin intermediate filament overproduction interferes with proper cross-linking and lipid organization, whereas reduced cornification further diminishes the formation of the protective stratum corneum; therefore the skin barrier function is weakened, rather than stratum corneum being thinner or wound healing enhanced.

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