In Alzheimer's disease, what distinguishes microglial TREM2 activation during the clearance of amyloid plaques, relative to its baseline function?

💡 Explanation

TREM2 activation stimulates microglial phagocytosis of amyloid-beta aggregates during plaque clearance because it increases the cells' ability to engulf and degrade these deposits. Therefore, option C is correct, rather than promoting inflammation (A), synaptic pruning (B), or tangle formation (D).

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