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Human Body & Health

If GLP-1 secretion is consistently inhibited, which consequence follows regarding insulin and glucagon regulation?

A)Increased liver glycogen synthesis occurs
B)Suppressed pancreatic beta-cell proliferation
C)Enhanced peripheral glucose uptake results
D)Impaired glucose-dependent insulin secretion

💡 Explanation

Impaired glucose-dependent insulin secretion results because GLP-1 stimulates insulin release in response to glucose and suppresses glucagon secretion. Without GLP-1, this glucose-dependent stimulation is lost, therefore the secretion is impaired, rather than enhanced, and beta-cell proliferation is not a direct consequence.

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