If neuronal autophagy declines in a patient with developing Alzheimer's disease, which consequence follows regarding neurodegenerative pathology?

💡 Explanation

When autophagy declines, the clearance of misfolded proteins, such as tau, is impaired. Because of reduced clearance via the autophagy pathway, tau protein aggregates accumulate, therefore exacerbating neurodegenerative pathology, rather than other processes like plaque formation being inhibited.

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