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← Human Body & HealthWhich effect results when cellular receptor tyrosine kinases are continuously activated by an endocrine hormone in the absence of a normal feedback signal?
A)Receptor internalization halts downstream signaling
B)Hormone production decreases via autocrine inhibition
C)Target cell sensitivity increases via receptor upregulation
D)Uncontrolled cell growth follows altered gene expression✓
💡 Explanation
Continuous tyrosine kinase activation bypasses normal regulatory mechanisms that control cell proliferation; because of this, cell cycle progression becomes unregulated, therefore leading to uncontrolled cell growth and potential oncogenesis, rather than receptor downregulation or hormone level changes.
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