If neurons accumulate abnormal protein aggregates like amyloid plaques, which consequence relating to proteasomal degradation becomes significant?

💡 Explanation

Protein aggregation impairs proteasomal degradation because the aggregates physically obstruct the proteasome's active sites, reducing substrate recognition and subsequent breakdown. Therefore, the degradation process is less effective, rather than transcription increasing or chaperones decreasing, since the proteasome's physical access to substrates is blocked.

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