If sustained liver damage prompts hepatic stellate cell activation and extracellular matrix deposition during cirrhosis, which consequence follows?

💡 Explanation

Hepatic stellate cell activation causes increased collagen production and fibrosis, leading to increased resistance to blood flow through the liver. Because of this increased resistance, portal hypertension develops, therefore the portal venous pressure will rise rather than decrease, and systemic pressures are affected secondarily.

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