If thrombolysis with tPA successfully restores blood flow to the ischemic penumbra after a stroke, which consequence follows regarding glutamate?

💡 Explanation

Following tPA treatment after a stroke, reperfusion can paradoxically worsen damage because of the sudden influx of oxygen and inflammatory cells, leading to oxidative stress that injures vulnerable penumbral tissue. Therefore, reperfusion injury becomes more pronounced rather than neuroprotection improving, because the damage to already compromised tissue exacerbates the stroke.

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