In erythrocytes, what causes hemolytic anemia when a G6PD deficiency exists during a malarial infection treated with primaquine?

💡 Explanation

The primary cause is oxidative stress because G6PD normally protects erythrocytes from oxidative damage; without it, primaquine exacerbates oxidative stress on the cells. This leads to hemolysis, therefore oxidative stress overwhelms defenses, rather than increased erythropoietin, iron storage, or ATP synthesis.

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