During high-altitude climbing, what distinguishes the increased diffusion of oxygen from alveoli to blood in acclimatized individuals, compared to non-acclimatized individuals?

💡 Explanation

Acclimatized individuals at high altitudes experience increased 2,3-DPG production. This right-shifts the hemoglobin-oxygen dissociation curve, weakening hemoglobin's affinity for oxygen, therefore facilitating oxygen unloading at tissues via enhanced diffusion from blood into cells, rather than hemoglobin retaining oxygen tightly.

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