If a patient develops angioedema during surgery due to latex allergy, which consequence follows regarding histamine's role?

💡 Explanation

Systemic vascular permeability increases due to histamine release from mast cell degranulation. Because histamine binds to endothelial cells, it causes increased inter-endothelial gaps, therefore leading to fluid extravasation and edema, rather than directly acting on arterioles or inhibiting mast cells.

• If a researcher introduces a modified MHC class I molecule that cannot bind beta-2 microglobulin into a human cell culture, which consequence follows regarding the adaptive immune response?
• If a novel enveloped virus binds ACE2 in human lung epithelial cells, stimulating the pyroptosis pathway in macrophages, which consequence follows?
• What causes increased pulmonary artery pressure secondary to chronic left-sided heart failure?
• If a patient exhibits persistent cognitive deficits post-concussion, even after initial symptoms subside, which mechanism explains the ongoing dysfunction at the neuronal level?
• Why does heatstroke, rather than fever, cause cognitive impairment, despite both conditions elevating core body temperature?
• If a cancer cell develops a mutation inhibiting an intrinsic apoptosis pathway while also increasing cyclin D expression, which consequence follows?