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Human Body & Health

What causes ascites in liver cirrhosis, specifically relating to the fibrotic tissue's impact on sinusoidal pressure?

A)Increased aldosterone and sodium retention
B)Renal tubular damage from hyperbilirubinemia
C)Portal hypertension and lymphatic leakage
D)Peripheral vasodilation with decreased oncotic pressure

💡 Explanation

Liver fibrosis increases resistance to blood flow, elevating portal pressure; this portal hypertension then forces fluid into the peritoneal cavity, leading to ascites because hydrostatic pressure overcomes oncotic pressure. Therefore, the correct answer is portal hypertension and lymphatic leakage rather than systemic changes.

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