What causes reduced sensation of fullness after eating in obese individuals with leptin resistance?

💡 Explanation

Obese individuals can develop leptin resistance, meaning the brain does not respond properly to leptin signals indicating satiety. Because hypothalamic leptin signaling is impaired, the satiety signals are not effectively relayed, leading to a reduced feeling of fullness; therefore, impaired signaling is the cause, rather than enhanced vagal nerve signaling.

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