What causes the initial depolarization of a Pacinian corpuscle, a mechanoreceptor in the skin, when it senses vibration?

💡 Explanation

Mechanical stimulation deforms the Pacinian corpuscle, causing mechanosensitive ion channels to open because this allows for the influx of positive ions, leading to depolarization; therefore, the opening of mechanically-gated channels is the answer, rather than voltage or ligand-gated ion channel activation.

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