What causes the reduced sensation of fullness after consuming fructose-sweetened beverages compared to glucose-sweetened beverages?

💡 Explanation

Fructose metabolism in the liver bypasses key regulatory steps that stimulate GLP-1 secretion in the gut, because decreased GLP-1 leads to less activation of satiety pathways in the brain. Therefore, fructose results in a blunted fullness response, rather than enhanced fullness, which is seen with glucose due to increased GLP-1.

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