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Which consequence diminishes the stability of the alpha helix structure?

A)Proline disrupts backbone hydrogen bonding
B)Hydrophobic forces promote tight coiling
C)Van der Waals repulsion stabilizes structure
D)Charged side-chains enhance ionic interactions

💡 Explanation

Alpha helix stability diminishes if proline is present because its rigid cyclic structure prevents amide hydrogen atoms participating in *hydrogen bonding*, therefore destabilizing the helix, rather than stabilizing it via hydrophobic interactions.

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