Which failure mode becomes more likely in the kidneys as the glomerular filtration rate decreases, increasing intratubular supersaturation with calcium oxalate?

💡 Explanation

Reduced glomerular filtration causes increased residence time of filtrate within the renal tubules; because the filtrate contains calcium and oxalate, this prolonged contact promotes supersaturation and subsequent calcium oxalate crystallization. Therefore, crystal formation accelerates, rather than reduced reabsorption or dilution, increasing stone risk.

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