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Life Sciences & Medicine

Which mechanism explains why Plasmodium falciparum expresses variant surface antigens during infection?

A)To enhance antibody-dependent cellular cytotoxicity
B)To promote rapid red blood cell lysis
C)To evade host antibody recognition
D)To stimulate complement activation pathways

💡 Explanation

Antigenic variation allows the parasite to express different surface proteins, evading the host's immune system. Because antibodies generated against one variant are ineffective against new variants, the parasite persists; therefore, antigenic variation explains immune evasion, rather than promoting cell lysis or complement activation.

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