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← ScienceWhich outcome results when polypeptide chains improperly fold within cellular cytoplasm?
A)Aggregation due to hydrophobic interactions✓
B)Enhanced enzymatic activity from altered conformation
C)Increased solubility from surface charge changes
D)Accelerated degradation by proteasome inhibitors
💡 Explanation
When polypeptide chains misfold, hydrophobic patches become exposed because the correct intramolecular hydrogen bonds do not form to stabilize the protein's tertiary structure, leading to intermolecular attractions and aggregation. Therefore, aggregation results, rather than enhanced activity, increased solubility, or accelerated degradation, which depend on proper folding.
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