Which risk increases when a chronic cortisol elevation suppresses pulsatile GnRH secretion?

💡 Explanation

Reduced bone mineral density risks increase. Chronic stress impedes the hypothalamic-pituitary-gonadal (HPG) axis via negative feedback, chronically suppressing pulsatile GnRH secretion. This causes sustained suppression rather than episodic GnRH, therefore reducing sex hormone output and bone mineral density, rather than increasing it.

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