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Which risk increases when a medical technetium-99m generator approaches its expiration date?

A)Breakthrough of molybdenum-99 increases
B)Zirconium-89 contamination decreases
C)Technetium-99m elution rate plateaus
D)Aluminum oxide column capacity increases

💡 Explanation

Breakthrough risk increases because the activity of the parent isotope molybdenum-99 decreases according to exponential decay, therefore higher proportions of unbound Mo-99 pass through the generator's column, rather than being retained like the Tc-99m product.

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